Crohn’s disease is a cell-mediated autoimmune i - belkin

[ArchivalUser]

Crohn™s disease is a cell-mediated autoimmune inflammatory disease of the colon. A new therapy uses humanized monoclonal antibodies to a cytokine, which breaks the cycle of inflammation. Antibody to which of the following cytokines would be appropriate therapy?


A. Interleukin-2 (IL-2)
B. Interleukin-4 (IL-4)
C. Interleukin-10 (IL-10)
D. Interleukin-12 (IL-12)
E. Transforming growth factor beta (TGF-beta

[ArchivalUser]

IL10...

[ArchivalUser]

try again ....

[ArchivalUser]

A?

[ArchivalUser]

Option D (Interleukin-12 (IL-12)) is correct. IL-12 is produced by myeloid cells (macrophage and dendritic cells) and initiates and then helps maintain Th1 responses and the production of interferon-gamma, which stimulates more production of IL-12, a cycle. Antibodies to IL-12 help break the cycle for a cell-mediated inflammatory disease such as Crohn™s disease.

[ArchivalUser]

yep....it stimulates production of IFN gamma...