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Haywood
In the first aid, it is said warfarin affects PT only. but since it antagonize vit.K and vit.K is involved in factors II, VII, IX and X, i think warfarin should affect APTT as well.
How do you guys think?
Please reply ASAP. Thanks.
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au
according to goljan, Heparin and Warfarin affect both, but they affect one more than the other, hence clinically there is a "favourite" test to monitor each
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locked-in syn. - doc_boc2000
It is a good Q though. Classically they used to say so, but it is true and the factor 2 and 10 which are for the common pathway are allso affected, but there is a point, the half life of facotr 7 is just 14 hours but for the formers is much longer, and also production of factor 7 is strongly affected by warfarin, but not that much for 2 and 10, therefor if you assess PT and aPTT of a patient who is under Coumadin, you will see that INR is for example 2 or 3, but the aPTT is just 20% increased.
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ABC
Many pts after MI, stroke, chronic afib & intermiitt claudication are put on both of these. So u should monitor, INR,PT, PTT.
If they are put on a combination of ASA, heparin, lovenox, coumadin. The side effects are GI bleeding & many others.
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Haywood
Good points. But if it appears in real test, would you consider Warfarin affects PT only?
Again, thank you for your support!
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locked-in syn. - doc_boc2000
Haywood, if you had both options choose it otherwise PT is the answer, if time was mentioned which was for a long time or the amount of increased aPTT was also mentioned which was less than 50% choose aPTT also (if applicable).
