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haptoglobin? - washaki

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haptoglobin? - washaki
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#1
09-17-2007, 06:32 AM
hemolytic anemia mech?
diseases?
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#2
09-17-2007, 06:48 AM
gOLJAN- SAID TO BE A SUICIDE PROTEIN IN PLACE OF HEMOGLOBIN.
ALWAYS REDUCED IN HEMOLYTIC ANAEMIA
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#3
09-17-2007, 06:50 AM
Haptoglobin is a marker for intravascular hemolysis always reduced
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#4
09-17-2007, 02:48 PM
thnx
-extra hemolysis: phagocytosis: RBC coated by IgG w or w/out C3b, orabnormal shape RBC, increase in serum unconjugated bilirubin, increase LDH
-intra hemolysis: enzyme deficiency G6PD, complement destruction, mechanical damage
haptoglobin: acute phase reactant that combine w Hb to form a complex that is phagocytosed and degraded by macrophage causing a degreee in serum haptoglobin/Hb in the complex is so small unconjugated bili is not significantly increased
disease cause : abnormal Hb, enzyme deficiency,membran defect, stenosis aortic valse, immune destruction
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