11-18-2007, 02:07 PM
. A 72-year-old man comes to the physician
because of generalized
weakness and night sweats for 6 months. During this
period he has had
a 5-kg (11-lb) weight loss. He has had polycythemia
vera for 12 years
treated with hydroxyurea and multiple phlebotomies.
Examination shows
cachexia. The liver is enlarged and nontender with a
span of 13 cm;
the spleen is enlarged. Hematocrit is 27%, leukocyte
count is 3200/mm3,
and platelet count is 150,000/mm3. A blood smear is
shown. Which of
the following is the most likely diagnosis?
A
) Acute myelogenous leukemia
B
) Cirrhosis of the liver
C
) Hodgkin's disease
D
) Miliary tuberculosis
E
) Myelofibrosis
because of generalized
weakness and night sweats for 6 months. During this
period he has had
a 5-kg (11-lb) weight loss. He has had polycythemia
vera for 12 years
treated with hydroxyurea and multiple phlebotomies.
Examination shows
cachexia. The liver is enlarged and nontender with a
span of 13 cm;
the spleen is enlarged. Hematocrit is 27%, leukocyte
count is 3200/mm3,
and platelet count is 150,000/mm3. A blood smear is
shown. Which of
the following is the most likely diagnosis?
A
) Acute myelogenous leukemia
B
) Cirrhosis of the liver
C
) Hodgkin's disease
D
) Miliary tuberculosis
E
) Myelofibrosis