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Under normal conditions in blood, which of the following amino acid residues of albumin is neutral?
Options:
1. Arginine
2. Aspartate
3. Glutamine
4. Glutamate
5. Histidine
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The Correct Answer is: Glutamine
Explanation:
In blood and other solutions at physiologic pH (approximately 7.0), only terminal carboxyl groups, terminal amino groups, and ionizable side chains of amino acid residues in proteins have charges. The basic amino acids lysine, arginine, and histidine have positive charges (protonated amines). The acidic amino acids aspartate and glutamate have negative charges (ionized carboxyls). Glutamine possesses an uncharged but hydrophilic side chain.