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a 75yr old man is brought to the physician by his family b/c of akinesia, rigidity,postural instability and tremor.symptoms improve with levodopa therapy but he develops anorexia nausea and vomiting and mild orthostatic hpotension. a drug with which of the following mechism of action is most appropriate to decreaase the gastrointestinal symptoms and hypotension?
a. inhibition of catecho-o-methlytransferase
b. inhibtion of monoxidase B
c. inhibiton of peripheral dopa decarboxylase
d. stimulation of cholinergic receptors
e. stimulation of dopamine receptors
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c. inhibiton of peripheral dopa decarboxylase
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aa
coz dec gi symptoms u have to activate sypathetic system and sympatheic system also inc pressure
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i think its ccc..
as GI distress is caused by peripheral action of dapamine on D1 receptors. and this could be decreased with carbidopa
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isy2007
what is the answer?
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Look: the nausea,anorexia and vomiting is the central effect of DA on the CTZ.
So I will choose D.
There will be excess stimulation of ACH receptors that overcomes the action of DA physiologically not pharmacologically.
Please post the answer isy2007.
