03-15-2008, 07:41 AM
Does anyone know y do u take aspirin for the side effects of niacin (pruritis/flushing)? That is written in Kaplan's hyperlipidemia section in Pharm notes.
|
? on Aspirin used for pruritis - kajol
|
03-15-2008, 07:43 AM
Because the pruritus and flushing is not mediated by histamine but araquidonic acid derivatives.
03-15-2008, 09:39 AM
i guess asprin is antiinflamatory and and arachdonic acid metabolites is blocked i dont think the above answer is right
03-15-2008, 11:44 AM
The pruritus caused by niacin is as a result of arachidonic acid derivatives and aspirin is an irreversible inhibitor of COX 1 and COX 2, so it blocks prostaglandin synthesis and consequently prevents the pruritus.
|
| « Next Oldest | Next Newest » |