04-12-2008, 05:19 AM
A 7-year-old African-American male child known to
be suffering from sickle cell anemia presents with severe
pain in the bones of the right hand. There is no associated
fever or leukocytosis. The most likely pathogenetic factor
in the causation of this pain is
O (A) Defects in the alternative complement pathway
O (B) Increased adhesion of red blood cells to the endo-
thelium
O © Erosion of bones from stimulation of erythropoiesis
O (D) Increased red blood cell sickling in the peripheral
tissues
O (E) Increased production of fetal hemoglobin
be suffering from sickle cell anemia presents with severe
pain in the bones of the right hand. There is no associated
fever or leukocytosis. The most likely pathogenetic factor
in the causation of this pain is
O (A) Defects in the alternative complement pathway
O (B) Increased adhesion of red blood cells to the endo-
thelium
O © Erosion of bones from stimulation of erythropoiesis
O (D) Increased red blood cell sickling in the peripheral
tissues
O (E) Increased production of fetal hemoglobin