04-29-2008, 07:31 PM
Q2
Alteration of which of the following influenza virus proteins is most likely to result in altered reactivity to neutralizing antibodies?
A ) Hemagglutinin
B ) Matrix protein
C ) Nonstructural protein
D ) Nucleoprotein
E ) Polymerase
Q3
. A 5-day-old female newborn who is breast-fed is brought to the emergency department because of a 1-day history of poor feeding, vomiting, and lethargy. Physical examination shows decreased responsiveness, hypotonia, and dehydration. There is a caramel-like odor in the diaper. Serum studies show a decreased glucose concentration, ketones, and metabolic acidosis. Metabolic studies of leukocytes show no conversion of [14C] leucine to 14CO2. An increased plasma concentration of which of the following substances is most likely in this patient?
A ) Alanine
B ) Isovaleric acid
C ) Methylmalonic acid
D ) Phenylalanine
E ) Propionic acid
F ) Valine
Q4
Sequence-specific cleavage of proteins plays a role in which of the following processes?
A ) Activation of G proteins by hormone receptors
B ) Assembly of microtubules
C ) Cellular uptake of iron
D ) Initiation of coagulation
E ) Transport of proteins into the nucleus
q5
In a population, the frequency of the HLA-A locus allele (A*01) is 0.20 and the frequency of the HLA-B locus allele (B*08) is 0.20. In the same population, the frequency of the haplotype A*01, B*08 is 0.16. Which of the following terms best explains the population characteristics of the observed frequency of the A*01, B*08 haplotype?
A ) Linkage disequilibrium
B ) Random assortment
C ) Somatic mutation
D ) Variable expressivity
Q7
The 45S rRNA precursor is cleaved into 18S, 5.8S, and 28S RNAs in which of the following?
A ) Endoplasmic reticulum
B ) Endosome
C ) Golgi complex
D ) Lysosome
E ) Nucleolus
q8
A geneticist has artificially produced a microorganism that contains a new combination of genes. He wants to know if recombination or transposition has occurred. The major difference between these two processes is that recombination involves which of the following?
A ) DNA repair
B ) Endonuclease sites
C ) Gene rearrangement
D ) Homologous sites
E ) Sites on the same chromosome
q10
A 55-year-old woman is treated with 500 mg of drug X three times daily for cancer pain. She is pain-free, but she develops nausea, vomiting, and diarrhea, requiring cessation of drug X. Drug Y is started at 20 mg twice daily. She is pain-free, her appetite improves, and she gains weight. Which of the following best describes the maximal efficacy of these drugs?
A ) Drug X is more efficacious than drug Y
B ) Drug Y is more efficacious than drug X
C ) Drugs X and Y are equally efficacious
11
When adipocyte triglycerides are mobilized, the nonfatty acid domain of this molecule can be used by the liver for gluconeogenesis. Which of the following enzymes initiates this process?
A ) 1,3-Diglycerate kinase
B ) Fructose 1,6-bisphosphatase
C ) Glucokinase
D ) Glyceraldehyde-3-phosphate dehydrogenase
E ) Glycerol kinase
F ) Hexokinase
Alteration of which of the following influenza virus proteins is most likely to result in altered reactivity to neutralizing antibodies?
A ) Hemagglutinin
B ) Matrix protein
C ) Nonstructural protein
D ) Nucleoprotein
E ) Polymerase
Q3
. A 5-day-old female newborn who is breast-fed is brought to the emergency department because of a 1-day history of poor feeding, vomiting, and lethargy. Physical examination shows decreased responsiveness, hypotonia, and dehydration. There is a caramel-like odor in the diaper. Serum studies show a decreased glucose concentration, ketones, and metabolic acidosis. Metabolic studies of leukocytes show no conversion of [14C] leucine to 14CO2. An increased plasma concentration of which of the following substances is most likely in this patient?
A ) Alanine
B ) Isovaleric acid
C ) Methylmalonic acid
D ) Phenylalanine
E ) Propionic acid
F ) Valine
Q4
Sequence-specific cleavage of proteins plays a role in which of the following processes?
A ) Activation of G proteins by hormone receptors
B ) Assembly of microtubules
C ) Cellular uptake of iron
D ) Initiation of coagulation
E ) Transport of proteins into the nucleus
q5
In a population, the frequency of the HLA-A locus allele (A*01) is 0.20 and the frequency of the HLA-B locus allele (B*08) is 0.20. In the same population, the frequency of the haplotype A*01, B*08 is 0.16. Which of the following terms best explains the population characteristics of the observed frequency of the A*01, B*08 haplotype?
A ) Linkage disequilibrium
B ) Random assortment
C ) Somatic mutation
D ) Variable expressivity
Q7
The 45S rRNA precursor is cleaved into 18S, 5.8S, and 28S RNAs in which of the following?
A ) Endoplasmic reticulum
B ) Endosome
C ) Golgi complex
D ) Lysosome
E ) Nucleolus
q8
A geneticist has artificially produced a microorganism that contains a new combination of genes. He wants to know if recombination or transposition has occurred. The major difference between these two processes is that recombination involves which of the following?
A ) DNA repair
B ) Endonuclease sites
C ) Gene rearrangement
D ) Homologous sites
E ) Sites on the same chromosome
q10
A 55-year-old woman is treated with 500 mg of drug X three times daily for cancer pain. She is pain-free, but she develops nausea, vomiting, and diarrhea, requiring cessation of drug X. Drug Y is started at 20 mg twice daily. She is pain-free, her appetite improves, and she gains weight. Which of the following best describes the maximal efficacy of these drugs?
A ) Drug X is more efficacious than drug Y
B ) Drug Y is more efficacious than drug X
C ) Drugs X and Y are equally efficacious
11
When adipocyte triglycerides are mobilized, the nonfatty acid domain of this molecule can be used by the liver for gluconeogenesis. Which of the following enzymes initiates this process?
A ) 1,3-Diglycerate kinase
B ) Fructose 1,6-bisphosphatase
C ) Glucokinase
D ) Glyceraldehyde-3-phosphate dehydrogenase
E ) Glycerol kinase
F ) Hexokinase