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A child has ingested cyanide from her parents™ garage and is rushed
to the emergency room. Which of the following components of the citric
acid cycle will be depleted first in this child?
a. NAD+ cofactor
b. Citrate synthase
c. Aconitase
d. Citrate production
e. Acetyl coenzyme A (CoA) production
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Talking abt Cyanide which cyanide comp use as a vasodialator therapy for the reduction in PB.
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Cyanide blocks respiration by displacing
oxygen from hemoglobin. Oxidative phosphorylation in the mitochondria
cannot proceed because cyanide cannot oxidize (remove electrons) from
reduced cofactors like NADH. The citric acid cycle is the major pathway for
generating ATP and reducing equivalents (NADH, H+) from catabolism of
carbohydrates, amino acids, and lipids. Inability to regenerate NAD+ from
NADH through mitochondrial oxidative phosphorylation depletes the cell
of NAD+ and inhibits the citric acid cycle. Failure to generate ATP by oxidative
phosphorylation using NADH from the citric acid cycle depletes the
cell of energy and leads to cell and tissue death (organ failure). Enzymes
(citrate synthase, aconitase) and intermediates of the citric acid cycle (citrate,
acetyl coenzyme A) need only be present in trace amounts because
they are not consumed.
