05-31-2008, 01:28 PM
aldolase-b deficiency why does it inhibit gluconeogenesis and glycogenolysis? Please explain this.
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Fructose intolerance - methadone08
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05-31-2008, 01:52 PM
aldolase B converts fructose -1- phosphate into Glyceraldehyde-3-phosphate which can be used as a substrate for glycolyis in well fed state or as a substrate for gluconeogenesis in starved state.
without aldolase B, fructose accumulates along with frucoose -1- phosphate and damages liver and kidneys. Also fasting hypoglycemia has low levels of glyceraldehyde-3-phosphate. So avoid table sugar (sucrose) / fructose in aldolase B deficiency. |
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