06-11-2008, 12:21 PM
A 46-year-old moderately obese woman is suffering from indigestion and regurgitation of acid that is worse after eating a large meal. She is treated with cimetidine. During the course of therapy, her serum creatinine concentration increases by 11%, with no other changes in serum electrolytes. The most likely explanation for the increase in serum creatinine is that cimetidine is
A. being reabsorbed by the nephron in exchange for creatinine
B. blocking synthesis of creatinine by skeletal muscle
C. causing acute renal failure
D. competing with creatinine for renal tubular secretion
E. inhibiting uptake of creatinine ingested with food
A. being reabsorbed by the nephron in exchange for creatinine
B. blocking synthesis of creatinine by skeletal muscle
C. causing acute renal failure
D. competing with creatinine for renal tubular secretion
E. inhibiting uptake of creatinine ingested with food