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A)decreases renal clearance
B)inhibitis tubular reabsorption
C)due to simulatneous induction of hypokalemia
D)due to simultaneous induction of hypomagnesemia
Mention the effect ( increase or decrease )of each drug on digoxin and match the mechanism
1)Quinidine
2)furosemide
3)hydrochlorthiazide
4)verapamil
5)spironolactone
6)diltiazem
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quinidine-a
frusemide,HCTZ-c,d
spironolactone-just guessing b
rest dont know
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Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and/or in volume of distribution of the drug,
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Erythromycin and clarithromycin (and possibly other macrolide antibiotics) and tetracycline may increase digoxin absorption in patients who inactivate digoxin by bacterial metabolism in the lower intestine,
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any one wants to try before the answer.
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1,4...A
2,3...C
5..decreases tubular secretion
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agree with to add
6-A
2,3 -- both C,D
