-hashimoto's- - pindi

[ArchivalUser]

Which of the following statements regarding hypothyroidism is true?

A. Hashimoto's thyroiditis is the most common cause of hypothyroidism worldwide.
B. The annual risk of developing overt clinical hypothyroidism from subclinical hypothyroidism
in patients with positive thyroid peroxidase (TPO) antibodies is 20%.
C. Histologically, Hashimoto's thyroiditis is characterized by marked infiltration of the thyroid
with activated T cells and B cells.
D. A low TSH level excludes the diagnosis of hypothyroidism.
E. Thyroid peroxidase antibodies are present in less than 50% of patients with autoimmune
hypothyroidism.

[ArchivalUser]

AAAAA?

[ArchivalUser]

A

[ArchivalUser]

seems to be A

[ArchivalUser]

A..........iodine deficiency

[ArchivalUser]

--- Corect answer is C....

Iodine deficiency is the most common worldwide cause of hypothyroidism.

Autoimmune, orHashimoto's, thyroiditis is a common cause in developed countries with dietary iodine supplementation. Histologically, it is characterized by lymphocytic infiltration of the thyroid with activated T cells and B cells.

Thyroid cell destruction is thought to be mediated by cytotoxic
CD8+ T lymphocytes. Primary hypothyroidism is characterized by an elevation in TSH as the
feedback inhibition of the anterior pituitary is diminished.

However, patients with hypothyroidism may have low TSH in the setting of secondary hypothyroidism. In this case, a clinical and radiologic evaluation of the pituitary is required.

~* ~ Subclinical hypothyroidism is characterized by abnormalities in the serum levels of TSH but minimal symptoms and often minimal change in the free T4 level.

The rate of development of overt, symptomatic
hypothyroidism is about 4% per year, especially in the case of positive TPO antibodies, which
are present in 90 to 95% of patients with autoimmune hypothyroidism

[ArchivalUser]

ok