01-03-2009, 02:11 PM
will go for C .. PNH .. pancytopenia and intravascular hemolysis resulting in decreased haptoglobin
A middle age patient presents with history of - dr2k2
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01-03-2009, 02:11 PM
will go for C .. PNH .. pancytopenia and intravascular hemolysis resulting in decreased haptoglobin
01-03-2009, 04:38 PM
Think C too. It's an intrinsic hemolytic anemia becuase of the cell membrane defect - and it is a intravascular hemolysis
01-03-2009, 05:20 PM
C. dec haptoglobin suggests intravascular hemolysis and positive sucrose hemolysis test suggests PNH wch is a membrane defect ie intrinsic hemolytic anemia.
01-04-2009, 04:22 AM
C is the correct answer
The patient most likely suffers from paroxysmal nocturnal hemoglobinuria, an acquired stem-cell disorder characterized by complement-induced hemolytic anemia, red urine (due to the appearance of hemoglobin in the urine) and thrombosis ( in this case in either the superior or inferior mesenteric vein causing ischemia). Erectile dysfunction is due to rapid destruction of the RBCs. A IS INCORRECT: Intrinsic hemolytic anemia/extravascular hemolysis most likely the case of sickle cell anemia. B IS INCORRECT: Extrinsic hemolytic anemia/intravascular hemolysis most likely the case of macroangiopathic hemolytic anemia (aortic stenosis, is the most common cause). D IS INCORRCT: Extrinsic hemolytic anemia/extravascular hemolysis most likely the case of warm autoimmune hemolytic anemia. E IS INCORRECT: Positive Direct Coombâ„¢s Test/extravascular hemolysis most likely the case of drug-induced hemolytic anemia. |
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