blood pressure change in isoproterenol - doc_vic

[ArchivalUser]

then beta1 effect doesn't have much to do with SBP except it increase Pulse pressure?

[ArchivalUser]

Isoproterenol---β1 &β2---> dec both MAP(β2) and diastolic BP(β2). in HR(β1)

dotutamine---β1>β2, what's the BP change?

[ArchivalUser]

and why it says in FA 230 that dobutamine has inotropic but not chronotropic effect vs dopamine. aren't b1 receptor supposed to have both inotropic&chronotropic effect?

[ArchivalUser]

I dont know!...Ii think FA is not correct at this issue!
because Dobutamine is a direct-acting agent whose primary activity results from stimulation of the β1-adrenoceptors of the heart, increasing contractility and cardiac output .

[ArchivalUser]

Dobutamine produces inotropic>chronotropic and also it has no effect on TPR so no reflex tachycardia too.

[ArchivalUser]

doc_vic

I think alisoviejo tells right. Dobutamine has both effect ( inotropic and chronotropic) but inotropic is >chronotropic !
and probably FA ( page 230) is not correct in this issue (inotropic but not chronotropic)!!!

[ArchivalUser]

you are both right, i thought the same finally

and the reason why SBP dec is because DBP dec is huge that leads to an dec in SBP

there is an initial transient in in SBP though