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Hyperviscosity in Waldenstr,s Macroglobulinemia is due to:
1. few RBC
2.few platelets
3.exsess amount of Ig M antibody
4.Exsess amount of plasma cells
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3 I would pick.
In Waldenstrom's the malignant cells are hybrids of B lymphocytes and plasma cells, not just pure plasma cells as in MM. Majority of the symphtoms in WM are due to the paraprotien JgM.
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it's in the definition: "Waldenstorm's is a lymphoproliferative disorder of excess IgM production" - answer is clearly 3
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answer 3
low RBC in W.Macroglobulinamie =anemia
low Platelets=bleeding and easy brusing,retinal vien bleeding
Infiltration and overproduction of plasma cells=big lever,big splen.big lymph nodes
Plasma cells produse Ig M antibody.Ig M overproduction couses thickening of the blood=hyperviscosity
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mamamia just wante to thank you for your effort in helping us.