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q3 - odin
#1
A 17-year-old boy presents to an outpatient psychiatry clinic with the chief complaint of facial tics and verbal outbursts. He reports that he experienced his first tic at 5 years of age, when he developed a repetitive nonrhythmic throat clearing in response to the persistent sensation that he had an unrelieved itch in the back of his throat. By 7 years of age, the throat-clearing persists, joined by forceful nasal exhalations and eye-blinking. As a teenager, he has all the old tics present together plus occasional bursts of shouted obscenities, racial slurs, and vulgarities that cause him great psychological distress as they often occur in the public setting. What is true of the verbal and motor tics that characterize this individualâ„¢s illness?

A. Increased frequency of tics occurs when patients are asleep
B. The majority of tics take the form of coprolalia (swearing or vulgarity)
C. There is a higher incidence of tics in females than males
D. There is a strong link between tics and obsessive-compulsive disorder (OCD)
E. Tics are exacerbated by use of dopaminergic agents
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#2
dd
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#3
DD
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#4
dd
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#5
Option D (There is a strong link between tics and obsessive-compulsive disorder (OCD)) is correct. Obsessions and compulsions occur in tic patients approximately 20 times more commonly than in the general population. In many cases, Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for OCD are met. Relatives also have markedly elevated rates of obsessions and compulsions, with or without tics.

Option A (Increased frequency of tics occurs when patients are asleep) is incorrect. The frequency and severity of tics improves during sleep.

Option B (The majority of tics take the form of coprolalia (swearing or vulgarity)) is incorrect. This type of complex tic, although popularly portrayed in the media, is seen in only 5% to 15% of patients with Tourette syndrome.

Option C (There is a higher incidence of tics in females than males) is incorrect. The reverse is true. There is a higher incidence of Tourette among males.

Option E (Tics are exacerbated by use of dopaminergic agents) is incorrect. This patient meets diagnostic criteria for Tourette syndrome, namely the presence of both motor and verbal tics, the chronicity and frequency of the symptoms, and onset before 18 years of age. Dopaminergic agents are often prescribed for Tourette syndrome as they have demonstrated good efficacy in treatment of tic disorders.
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#6
I agree the answer is DDD...

But regarding option eeee
The basic cause in Tourette is increse in dopamine...
Here the treatment is antipsychotic drugs.. like pimozide haloperidol, resperidone
So how do u justify the option EEE is incorrect here....
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#7
The role of dopamine in Tourette syndeome is not yet completely understood. Some studies showed that dopaminergic drugs improve the symptoms.

http://emedicine.medscape.com/article/1182258-overview
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