7methylG capping in nucleus or cytopolasm - laiba07

[ArchivalUser]

according 2 fa &kaplan it,s in nucleus but uw said it,s in cytoplasm what,s correct

[ArchivalUser]

i thought it was in nucleus

[ArchivalUser]

bc it gets spliced in cyto from pre-mrna to mrna

[ArchivalUser]

capping--- one of the post transcriptional modification process

has 2 steps'

1st.....>addition of GTP--

GTP+ 5'end of mRNA------by Guanayl tranferase......>5'guanasine cap--occurs in NUCLEUS

2nd---->methylation',

methylation+5'G.cap---by guanasine 7 methyl transferase(SAM).....>5'methylated guanasine cap....occurs in CYTOPLASM..

[ArchivalUser]

thanx ksstep ,dr bkc where can i find this cytoplasmic posttrascriptional modificationb/c my concept was transcription completed in nucleus and translation occur in cytoplasm .found alternative splicing eg variants of tropomyosin &troponin,synthysis of memb bound Ig vs secreted Ig, DAreceptor i n brain made from 1 gene(kaplan bio chapter 3)

[ArchivalUser]

u can see ..lippincot biochem..

add one more Example for alternative splicing product s FIBRONECTIN