Posts: 3,675,937
Threads: 734,344
Joined:
Sep 2021
Reputation:
5
hi all,
please help me with these q's:
1) by what age are the enzymes for glucuronidation complete? is it one year?
2)what exactly is torsade de pointes? an arrhythmia caused by elongated action potential duration , so it follows, a common complication of k channel blockers.. how does it cause syncope?
3)please list drugs for
a) drug induced sle
b)drug induced pk (any besides phenothiazines?)
plus treatment for the same.
lastly, a genetics q: is there any diff bw transgenic mice and knockout mice?
Posts: 3,675,937
Threads: 734,344
Joined:
Sep 2021
Reputation:
5
transgenic mice is the one in which a foreign gene is introduced for ur study.
KO mice is one in which the the endogenous gene of a mice has been dsrupted to study its function.
Posts: 3,675,937
Threads: 734,344
Joined:
Sep 2021
Reputation:
5
torsade de pointes
causes ---> quinidine
digoxin
tricyclic depressant
liquid protein diet
intra cranial events
third degree block
congenital anomaly
Posts: 3,675,937
Threads: 734,344
Joined:
Sep 2021
Reputation:
5
torsades de pointes
abnormalities of ventricular repolarization( prolongation of QT interval) r at risk to develop polymorphic ventricular tachycardia( torsades de pointes) -----> syncope
inherited form of this syndrome hav family history of sudden death in young individuals called familial long QT syndrone
Posts: 3,675,937
Threads: 734,344
Joined:
Sep 2021
Reputation:
5
drug induced SLE
proiaeneamide
disopyramide
profenone
hydralazine
ACE inhibitors(several)
beta blockers
propylthiouracil
chlorpromazine
lithium
carbamazepine. phenytoin
isoniazid , minocycline
sulfasalazine
hydrochlorothiazide
lovastatin simvastatin
interferons
TNF inhibitors
