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Which of the following is a characteristic of antibodies blood group (ABO) hemolytic disease of the newborn (HDN) rather than Rh HDN due to anti-D?
A. Age-adjusted normocytic anemia
B. Newborn may develop anemia and jaundice in the first pregnancy
C. Positive direct Coombs™ test on babies cord RBCs
D. Severe anemia requiring an exchange transfusion
E. Unconjugated hyperbilirubinemia
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bb ABO incompatability present in 1st pregenancy while RH in second pregenancy..
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basiq is right. bbb. here is the expl
In ABO HDN, the majority of O mothers already have anti A, B-IgG natural antibodies that react with antigens in blood group A and B RBCs. Since IgG crosses the placenta, if the fetus is blood group A or B, the antibody will attach to the RBC and be removed by fetal splenic macrophages leading to a mild extravascular hemolytic anemia. In Rh HDN due to anti-D, the mother must first be sensitized by an Rh positive fetus before antibodies can cross the placenta and hemolyze fetal Rh positive cells in future pregnancies.
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yeah though unconjugated bilurubinemia is seen but I was also debating for the correct answer to be B
