Pharm questions - p.patel

[ArchivalUser]

I learned that estrogen is P450 dependent. And that drugs that inhibit p450, increase estrogen - which is why they cause gynecomastia (Spironolactone, ketoconazole, etc.)

So how does alcohol (which increases P450), cause gynecomastia?

Just curious, so if anyone could answer, it'd be great! Thanks.

[ArchivalUser]

gynacomastia in alcoholic cirrhosis , is due to decrease catabolism of androstenedion .
inc. androstenedion is responsible for inc. conversion of androgens to estrogen in the tissues. this is the mech. as i understand it ...

[ArchivalUser]

Also, in alcoholic cirrhosis,estrogen catabolism in the liver is decreased and hence leads to increased periferal action of estrogen leading to gynecomastia as I understand.

[ArchivalUser]

Thanks guys!! Duh, I forgot about alcoholic cirrhosis