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A 35-year-old Caucasian female wants to undergo chorionic villous sampling at 10 weeks of gestation for detection of possible Down™s syndrome in her baby. She decided to have this procedure after increased nuchal translucency was found on her first trimester ultrasound. She read on the internet that the procedure is associated with limb reduction anomaly, and she wants to know what factors are responsible for the increased risk of this anomaly. Which of the following is the best response?
A. The risk depends upon the skill of the operator
B. The risk depends upon the age of gestation
C. The risk depends upon the route of the procedure
D. The risk depends upon the gauge of the needle used for the procedure
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Early chorionic villus sampling
In 1991 a report from Oxford3 first suggested the link between chorionic villus
sampling (CVS) and severe limb deficiencies. Further studies confirmed this
association with defects where the distal part of one or more limbs or digits is missing
across its entire width (transverse terminal deficiency) The earlier in pregnancy that
CVS took place the more extensive the defect. It is thought that it causes disruption
of the normal blood supply to cartilage. The risk decreases as pregnancy advances,
so CVS is now not performed before 10 weeks gestation.
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Early chorionic villus sampling
In 1991 a report from Oxford3 first suggested the link between chorionic villus
sampling (CVS) and severe limb deficiencies. Further studies confirmed this
association with defects where the distal part of one or more limbs or digits is missing
across its entire width (transverse terminal deficiency) The earlier in pregnancy that
CVS took place the more extensive the defect. It is thought that it causes disruption
of the normal blood supply to cartilage. The risk decreases as pregnancy advances,
so CVS is now not performed before 10 weeks gestation.
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very well explained thanku
