nbme 3 block 1 q 9 - basalganglia

[ArchivalUser]

Can anyone pls explain that graph and calculation?Thanks

[ArchivalUser]

hi basalganglia....can u check the question...I cant se any graph...

[ArchivalUser]

yeabiruh i think its in block 4 Q9

[ArchivalUser]

my understanding is the question is asking us about the steady state concentration

---and the time to reach steady state concentration is dependent only on the elimination half life of a drug and is indepndent of dose size and frequency of adminstration(from kaplan)

--to calculate the half life of this antibiotic...first look at the starting dose(which is 20 )...the half life of this antibiotic should decrease this value by half...to 10..then look at the value in the x axis (time) which corresponds with 10...it is 3 ...hence the half life is 3 hours

--by the way the graph is also an example of first order elimination and half life is constant and u can check for the other drug concentrations as well..

--hence clinical steady state (95 %)is accepted to be reached at 4-5 multiplied by half life

--this gives us for 97 % approximately 5 * 3(the half life)=15

my answer C

[ArchivalUser]

Thnak u yeabiruh