04-07-2011, 03:18 PM
A 2 y/o boy is brought to the office due to recurrent skin and soft tissue infections.When he was two months old he had a perianal furuncle that was incised and drained because it was unresponsive to oral antibiotics.At 7 months of age he had a left inguinal klebsiella pneumoniae lymphadenitis.His other past infections include a left calf cellulitis that grew serratia marcescens and a left inguinal abscess that grew staph epidermidis.On examination he has hepatosplenomegaly and enlarged axillary and inguinal lymph nodes.The screening tests for humoral and cell mediated and complement-mediated immunity are normal.The nitroblue tetrazolium test is abnormal.What is the most likely Dx?
A-Wiskott-Aldrich syndrome
B-Chediak-Higashi syndrome
C-Chronic Granulomatous disease
D-Leukocyte adhesion defect
E-Job's Syndrome
A-Wiskott-Aldrich syndrome
B-Chediak-Higashi syndrome
C-Chronic Granulomatous disease
D-Leukocyte adhesion defect
E-Job's Syndrome