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anything related to NFkB inhibition by predniso?? - versatile58

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anything related to NFkB inhibition by predniso?? - versatile58
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#1
06-01-2011, 03:23 PM
history about CLL(very long history) then at the end what MOA of prednisone in treating this tumor?
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#2
06-01-2011, 04:44 PM
Steroids induce apoptosis of malignant lymphocytes by inhibiting NFkB.
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#3
06-01-2011, 04:48 PM
NFkB is a group of transcriptional foctors that is anti-apoptotic especially in streesed cells (eg malignant cells). So inhibiting this factor induces apoptosis in maligant cells.
I think steroids do that by inhibiting some proinflammatory cytokins ..i am not sure
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