Cyclophosphamide - billll

[ArchivalUser]

Q) A patient on cyclophosphamide experiences sharper decline in renal and pulmonary function when a second drug is added to his regimen. Which is the second drug added?

A. Dactinomycin.
B. Methotrexate.
C. Prednisone.
D. Vinblastine.
E. Vincristine.

Kindly substantiate your answers.

[ArchivalUser]

B.

[ArchivalUser]

I guess it is because of a additive immunosuppression effect of methotrexate, leading to renal and pulmonary infections.......could some one elaborate on this ?

[ArchivalUser]

E :

[ArchivalUser]

methotrexate produces renal and pulmonary toxicity among the choices....none of others have this effect....