07-11-2011, 07:44 AM
A 40 year old man is at risk for an autosomal dominant neurodegenerative disorder caused by Trinucleotide repeat expansion. Molecular diagnostic analysis of his DNA shows a normal allele and an allele with expansion of codon CAG encoding glutamine within exon 2 of the responsible gene as shown. Risk estimates for various CAG repeat numbers are shown in the graph Based on this information. Which of the following is the best estimate of the likelihood that this man will develop this disorder?
what is answer?... Maybe A?
I found that
http://genetics.medicine.iu.edu/division...ton-facts/
To clarify this further, the number of CAG repeats has been divided into the following 4 categories.
CAG REPEAT SIZE INTERPRETATION
26 and below Normal
27-35 Not predictive of HD. May or may not be stably transmitted
36-39 MAY BE predictive of HD. Not stably transmitted
40 and above HD. Not stably transmitted
what is answer?... Maybe A?
I found that
http://genetics.medicine.iu.edu/division...ton-facts/
To clarify this further, the number of CAG repeats has been divided into the following 4 categories.
CAG REPEAT SIZE INTERPRETATION
26 and below Normal
27-35 Not predictive of HD. May or may not be stably transmitted
36-39 MAY BE predictive of HD. Not stably transmitted
40 and above HD. Not stably transmitted