Non NBME qn?? - aalizzwell2010

[ArchivalUser]

a pt with PUD using diazepam then he get very sleepiness due to which drug he is using??

A.ranitidine
B.propantheline
C.omeprazole
D.cimetidine

[ArchivalUser]

D.

[ArchivalUser]

DD

[ArchivalUser]

ddd

[ArchivalUser]

agree with ur ans but in kaplan it is given as PPIs decrease the excretion of diazepam,phenytoin and warfarin then y dont we pick OMEPRAZOLE????it is given in 2008 kaplan pharma bokk but not in 2010 it is deleted in new book..sooo

[ArchivalUser]

@ allizwell. in nbme 6 there was a q on PPIs which i got wrong so i researched on internet n found ppis as inducer of cyp inducer. so here if u take as inducer then decreased sleepiness.

[ArchivalUser]

no notym u r wrong again ppts r inhibitors not inducers>>>>iam sure u plz chek once again

[ArchivalUser]

@ allizwell i copy pasted that info at that time so i dont hav the link n i cant giv u refrence but if u can giv me refrence i will agree coz i hav no energy to research on it further. so as for nw i take it as an inducer unti proven otherwise lol.


Poor metabolizers of CYP2D6 substrates are at risk for postural hypotension and antipsychotic side effects such as oversedation, because several antipsychotic agents are metabolized by CYP2D6.14

Of the antidepressants, paroxetine (Paxil) appears to have the greatest ability to inhibit the metabolism of CYP2D6 substrates

Inducers
Omeprazole (Prilosec)
Phenobarbital
Phenytoin (Dilantin)
Rifampin (Rifadin, Rimactane)
Smoking
Charcoal-broiled meat *

[ArchivalUser]

@ allizwell its the same nbme 6 q u posted .. plz name it as nbme coz other ppl might not want to ans nbme..