Question.............. - psychmledr

[ArchivalUser]

Q3. In a child diagnosed with a T-cell lymphoma, the phenotype of malignant cells matches that of normal progenitor cells that leave the bone marrow to go to the thymus.
What cell surface markers would be found on those malignant cells?

A. CD4+, CD8+, TCR+
B. CD4+, CD8-, TCR+
C. CD4-, CD8+, TCR+
D. CD4-, CD8-, TCR+
E. CD4-, CD8-, TCR-

[ArchivalUser]

EE

[ArchivalUser]

E..

[ArchivalUser]

Yes "E" is right because progenitor T-cells that leave the bone marrow have neither CD4 nor CD8 coreceptors, nor have they rearranged the DNA of the variable domains of their antigen receptor, the TCR...........as per Kaplan.

To me they seem like unarmed soldiers

Have a great day

[ArchivalUser]

eeeee

[ArchivalUser]

dd