mopp - hothellguy

[ArchivalUser]

MOPP is a combination chemotherapy regimen used to treat Hodgkin's disease. The acronym is derived from the component drugs of the regimen:

Mustargen (also known as mechlorethamine, mustine, nitrogen mustard, or MSD)
Oncovin (also known as Vincristine or VCR)
Procarbazine (also known as Matulane or Natulan)
Prednisone (also known as Deltasone or Orasone)

The treatment is usually administered in four week cycles, often for six cycles. MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. A newer Hodgkin's lymphoma treatment is ABVD.

[ArchivalUser]

ABVD is a chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma, supplanting the older MOPP protocol. It consists of concurrent treatment with the chemotherapy drugs:
Adriamycin (doxorubicin/Hydroxydaunorubicin, the H in CHOP)
bleomycin
vinblastine
dacarbazine (similar to Procarbazine, the P in MOPP)

[ArchivalUser]

One cycle of ABVD chemotherapy is typically given over 4 weeks, with two doses in each cycle (on day 1 and day 15). All four of the chemotherapy drugs are given intravenously. ABVD chemotherapy is usually given in the outpatient setting — that is, it does not require hospitalization.

Typical dosages for one 28-day cycle of ABVD are as follows
Adriamycin 25 mg/m2 IV on days 1 and 15
Bleomycin 10 units/m2 IV on days 1 and 15
Vinblastine 6 mg/m2 IV on days 1 and 15
Dacarbazine 375 mg/m2 IV on days 1 and 15

The total number of cycles given depends upon the stage of the disease and how well the patient tolerates chemotherapy. Doses may be delayed because of neutropenia, thrombocytopenia, or other side effects.