nbme 12 qus - k2011

[ArchivalUser]

a healthy 24 year old man comes to nthe physician for a follow up visit. onemonth ago he received the first recomb hep B vaccine dose. he is scheduled to receive the second dose f the vaccine today. which of following describes the likely antibody response against surface antigen in this patient after the second dose comapred with thE response after the initial dose?

A HIGHER RATIO OF SERUM IgG to IgM and an earlier IgG peak
B HIGHER RATIO OF SERUM IgG to IgM and a later IgG peak
C lOWER RATION OF SERUM IgG TO IGm and an earlier IgG PEAK
DLOWER RATIO OF SERUM IgG to serum IgM and and a later IgG PEAK

PLEASE EXPLAIN AS MUCH AS POSS THANKS

[ArchivalUser]

anyONE??????????????????????????????????????

[ArchivalUser]

EXPLANATIONS PLEASE

[ArchivalUser]

NO RESPONSE???????????

[ArchivalUser]

its a
coz when the second dose is given... the sensitised cellss (from previous dose) get stimulated, and they secrete IgG... so IgG>IgM
since the immune system already recognises this antigen, the IgG peak will occur earlier coz of the memory cells
just see the diagram in kaplan micro under immunization, it talks in respect to infection after immunization.. its the same concept here

but wht i dont understand is y do we need multiple booster doses?

[ArchivalUser]

its A i got that right....

one the second exposure you should have igG and also from the first time as it became old those igM turned to ig G i hope that helps