Q________ph 3_______? - goal13

[ArchivalUser]

" USE DEPENDANCE" is a phenomenon observed with regard to the pharmacokinetic properties of anti arrythmic agents which of the following antiarrythmic exhibits this phenomenon

A quinidine
B Mexiletine
C Propranolol
D flecainide

[ArchivalUser]

Donnowhy..lol but will go for
Cccc

[ArchivalUser]

as I know class III aa

[ArchivalUser]

During faster heart rates, less time exists for the drug to dissociate from the receptor, resulting in an increased number of blocked channels and enhanced blockade.

This property is known as use-dependence"

and is

seen most frequently with the class IC agents