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que_____________ - targt250
#1
A 57-year-old African-American man presents
to his physician with gradual onset of pain in
the right leg over 3 months, and acute onset of
back pain. He reports that the pain is right on
the bone and becomes worse with walking. He
does not recall any inciting trauma to the leg.
He has no chronic illnesses but reports two episodes
of pyelonephritis over the last 18 months.
Review of systems is signifi cant for mild fatigue.
Physical examination shows tenderness
along the right femur with no pain on straight
leg raise. The legs are warm to the touch with
good pulses and no sensory or motor defi cit.
No abdominal bruit is heard. Laboratory results
are signifi cant for hypercalcemia, elevated
creatinine, and a low hemoglobin level. X-ray
of the spine reveals compression fractures.
Which of the following additional tests would
confi rm the most likely diagnosis?
(A) Abdominal ultrasound showing stenosis of
the right iliac artery
(B) Bone densitometry with diminished
T-score
© Bone marrow biopsy showing plasmacytosis
(D) Decreased serum vitamin D level
(E) Nerve conduction studies
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#2
happy sunday folks,,,
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#3
same to you targt250 and thanx a loooooooot for the ques.....
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#4
Multiple myeloma

CC
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#5
ccc
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#6
the same wishes to you target 250

Thank you for nice qs
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#7
u r welcome Smile

correct answer is C. Multiple myeloma is
a malignant proliferation of plasma cells,
which causes them to overproduce monoclonal
immunoglobulin. Due to the defective immune
system, patients will often have recurrent
infections, of which pneumonia and pyelonephritis
are the most common. Patients developbone pain that is worse with movement, lytic
bone lesions, compression fractures, and hypercalcemia
due to increased osteoclast activity.
Renal failure is also common due to deposition
of antibody light chains and associated
renal amyloidosis. Diagnosis is aided by a bone
marrow biopsy showing a clonal plasma cell
population of >10% of the marrow, monoclonal
immunoglobulin (M component) in the
serum or the urine, and other features like lytic
bone lesions, anemia, and elevated serum calcium.
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#8
multiple myeloma
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