Adenosine Receptors___________ - psychmledr

[ArchivalUser]

What can you tell me about them?

Which ones are important? What is A1, A2? What is their MOA?

Thank you

[ArchivalUser]

they have Gi coupled receptor in heart->slow down heart rate SA AV nodal conduction
Gq coupled in bronchi->bronchoconstriction, similar to muscarinic receptor in lungs
according to Kaplan pharm

[ArchivalUser]

Thank you. I agree that is what is in Kaplan pharma. And that's all that is mentioned about it.

What about adenosine receptors in the blood vessels? Adenosine causes vasodilation. I believe it works by stimulating adenyl cyclase and so it increases cAMP concentration.

So which type is referred to as A1 and which is A2?

Thanks again for your input

[ArchivalUser]

A1: has the inhibitory action
A2: increases cAMP(in basal ganglia target for caffeine) also vasodilatation

Thankyou

[ArchivalUser]

They also increase coronary blood flow in the heart

[ArchivalUser]

Thank you all.

[ArchivalUser]

Thank you for the question!!!