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path Q - sage2006
#1
which one of following situation describes a major risk factor for early-onset familial Alzheimer disease?

1. expansion of CAG trinucleotide repeats on chromosome 4
2. ingestion of 1-methyl-4-phenyl-tetraphydrobioperidine
3. mutations in the genes encoding for presenilins
4. mutations in the SOD1 gene
5. the presence of the E4 isoptype of ApoE
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#2
3)
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#3
correct.
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