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Stroke prevention Q - eric88
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03-30-2006, 04:51 AM
Patients taking ticlopidine (Ticlid) as an alternative to aspirin or other stroke prevention medications must be initially monitored every 2 weeks with A. a CBC B. a lipid profile C. a urinalysis D. a serum creatinine level E. FOBT
03-30-2006, 05:11 AM
A, a CBC. Ticlopidine causes severe Neutropenia and Thrombopenia
03-30-2006, 05:20 AM
it is ticlopidine which can cause agranlocytosis so you must do cbc .
other drugs where you have to monitor wbc count are propylthiouracil and neomercazole used in thyrotoxicosis/ clozapine used in negative symtomed and refractory schzinophrenia or other psychosis./ anticonvulsant like carbamazepine though liver fn is mmore important/chlomphenicol. whenover these pt have pharyngitis kind of symtoms ask them to report because thatmay be the starting of agranulocytosis. does ticlopidine cause throbocytopenia also---bible ?
03-30-2006, 09:47 AM
That is why it is off the market.... severe neutropenia. There are other medications that cause neutropenia that are still in use..for example CARBAMAZEPINE.
03-30-2006, 10:01 AM
djyoti , thanks for the question. Indeed the side effects of Ticlopidin are vast, throbocytopenia being one of them, but "it seldom causes throbocytopenia".
03-30-2006, 12:02 PM
djyoti, good summary of these drugs. A is the answer.
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