06-03-2017, 08:37 AM
Patients with celiac disease have diarrhea with voluminous, foul-smelling and floating stools due to steatorrhea. Patients, especially later in the course of the disease, may present with non-gastrointestinal manifestations such as iron-deficiency anemia, vitamin D and calcium deficiency, thereby causing osteopenia, osteomalacia, arthritis, and significant weight loss.
The mainstay of diagnosis of celiac disease is a small intestinal biopsy. Biopsies are usually taken from the distal duodenum during an upper GI endoscopy. The characteristic histologic findings are :-
A. Transmural inflammation with lymphocytic infiltration
B. Superficial mucosal inflammation with infiltration of plasma cells
C. Villus blunting with lymphocytic and plasma cell infiltration
D. Diffuse hypertrophy of the intestinal villi
E. Polyp formation in the small intestine
The mainstay of diagnosis of celiac disease is a small intestinal biopsy. Biopsies are usually taken from the distal duodenum during an upper GI endoscopy. The characteristic histologic findings are :-
A. Transmural inflammation with lymphocytic infiltration
B. Superficial mucosal inflammation with infiltration of plasma cells
C. Villus blunting with lymphocytic and plasma cell infiltration
D. Diffuse hypertrophy of the intestinal villi
E. Polyp formation in the small intestine