08-07-2017, 09:19 PM
Present with severe abdominal pain.
Porphyrias
Intermittent: Neurovisceral S/S, Erythropietic: Painful skin and acute swelling and Cutanea Tarda: chronic blistering skin lesion.
WATSON-SCHWARTZ TEST detects porphobilinogen in urine, and is used in the Dx of PORPHYRIAS
INTERMITTENT -------------------------------------> URINE PORPHOBILINOGEN
ERYTHROPOIETIC ----------------------------------> ERYTHROCYTE PORPHYRINS AND PLASMA PROPHYRINS.
CUTANEA TARDA -----------------------------------> URINE PORPHYRIN AND SECOND FECAL PORPHYRIN.
Porphyria Cutanea Tarda
Plasma Porphyrins + Uroporphyrin I (urine) + Isocoproporphyrin (feces) are ELEVATED. Present w/either abdominal pain or chronic skin blistering.
Blisters and Crusted lesions on Sun-exposed skin of face and lower arms + CATERPILLAR BODIES
Porphyrias
Intermittent: Neurovisceral S/S, Erythropietic: Painful skin and acute swelling and Cutanea Tarda: chronic blistering skin lesion.
WATSON-SCHWARTZ TEST detects porphobilinogen in urine, and is used in the Dx of PORPHYRIAS
INTERMITTENT -------------------------------------> URINE PORPHOBILINOGEN
ERYTHROPOIETIC ----------------------------------> ERYTHROCYTE PORPHYRINS AND PLASMA PROPHYRINS.
CUTANEA TARDA -----------------------------------> URINE PORPHYRIN AND SECOND FECAL PORPHYRIN.
Porphyria Cutanea Tarda
Plasma Porphyrins + Uroporphyrin I (urine) + Isocoproporphyrin (feces) are ELEVATED. Present w/either abdominal pain or chronic skin blistering.
Blisters and Crusted lesions on Sun-exposed skin of face and lower arms + CATERPILLAR BODIES