08-07-2017, 09:54 PM
Mieloid Blasts + Auer Rods. Subtype M3 can be complicated with DIC during TX. Also call Acute PROMYELOCYTIC leukemia
D.I.C
It is seem as a complication in the Tx of A.M.L. (Acute Myelogenous Leukemia).
Chromosome t(6;9)(p23;q34) translocation is found in subtypes of AML with basophilia (M1, M2, M4)
Chromosome t(8;21)(q22:q22) translocation is see in M2 leukemia, also known as acute myeloid leukemia (AML) with maturation, and some M4 (AML with granulocytic and monocytic maturation).
Chromosome t(15:17) is the translocation related with the development of D.I.C in Pts w/AML also call Acute promyelocytic Leukemia.
It is classified by FAB (French American British), AML is a translocation. The classification is: M1, M2, M3, M4, M5, M6 and M7
M1 and M7 are very very rare.
M2 or Myeloblastic Leukemia w/ maturation has blast more than 30%, w/ more 50% of the blasts being myeloblasts and promyelocytes.
In M2 we can see mature forms. Eosinophils may be heavy in some cases.
M3 or Hypergranular Promyelocytic Leukemia has Blast more than 30%.
In M3 the majority of cells have a promyelocytic appearance w/ kidney-shaped nuclei. Auer rods are usually seen in the cytoplasm
M4 or Myelomonocytic Leukemia has Blast more than 30% with promonocyts and monocytes accounting for more than 20% of the bone marrow aspirate
M5 or Monocytic Leukemia, is divided into differentiated and poorly differentiated.
M5 has more than 30% blasts, the granulocyte component is less than 10% of marrow cells.
In M5 the monocytes can be detected cytochemically with the fluoride-sensitive esterase reaction.
M6 have Blasts more than 30% of which more than 50% are erythroblasts. 50% of AML patients have elevated WBCs.
M6 S/S malaise, pallor, low grade fever and weight loss.
Can be Tx with Retinoid Acid (Vit A). Because Vit A mature the blast in that way the malignant cell become benign.
D.I.C
It is seem as a complication in the Tx of A.M.L. (Acute Myelogenous Leukemia).
Chromosome t(6;9)(p23;q34) translocation is found in subtypes of AML with basophilia (M1, M2, M4)
Chromosome t(8;21)(q22:q22) translocation is see in M2 leukemia, also known as acute myeloid leukemia (AML) with maturation, and some M4 (AML with granulocytic and monocytic maturation).
Chromosome t(15:17) is the translocation related with the development of D.I.C in Pts w/AML also call Acute promyelocytic Leukemia.
It is classified by FAB (French American British), AML is a translocation. The classification is: M1, M2, M3, M4, M5, M6 and M7
M1 and M7 are very very rare.
M2 or Myeloblastic Leukemia w/ maturation has blast more than 30%, w/ more 50% of the blasts being myeloblasts and promyelocytes.
In M2 we can see mature forms. Eosinophils may be heavy in some cases.
M3 or Hypergranular Promyelocytic Leukemia has Blast more than 30%.
In M3 the majority of cells have a promyelocytic appearance w/ kidney-shaped nuclei. Auer rods are usually seen in the cytoplasm
M4 or Myelomonocytic Leukemia has Blast more than 30% with promonocyts and monocytes accounting for more than 20% of the bone marrow aspirate
M5 or Monocytic Leukemia, is divided into differentiated and poorly differentiated.
M5 has more than 30% blasts, the granulocyte component is less than 10% of marrow cells.
In M5 the monocytes can be detected cytochemically with the fluoride-sensitive esterase reaction.
M6 have Blasts more than 30% of which more than 50% are erythroblasts. 50% of AML patients have elevated WBCs.
M6 S/S malaise, pallor, low grade fever and weight loss.
Can be Tx with Retinoid Acid (Vit A). Because Vit A mature the blast in that way the malignant cell become benign.