nbme16 q - bagira

[ArchivalUser]

A 42 year old woman undergoes biopsy of suspicious calcifications seen on routine mammograms. Light microscopy shows a poorly demarcated region consisting of poorly cohesive cells growing in sheets. The nucleus to cytoplasmic ratio approaches 1.1, and prominent nucleoli are observed there is microscopic evidence of invasion into stromal tissues. She has no adenopathy ct scans show no evidence of hepatic pulmonary or bone metastases. These findings are most consistent with which of the following?
A) High grade, high stage neoplasm
B) High grade, low stage neoplasm
C) Low grade, High stage neoplasm
D) Low grade , low stage neoplasms

???

[ArchivalUser]

Ans is B
but it is invading stroma. doesnt that make it high stage?

[ArchivalUser]

Prognosis base on / & Staging is based on SIZE (1ry lesion)/extend of spread to regional LN & presence or absence of blood-borne met on is most frequently reported using TNM system. Most pat usually don’t show up with M, so which one would for be the most useful factor?

In 5 more months that gone change for breast cancer. But now that’s all u need to know to ans nb Qs.

You ans my Q it means u got it.

[ArchivalUser]

Thx cardio.
Got the point.

[ArchivalUser]

Welcome.
Try this Q http://www.usmleforum.com/showthread.php?tid=843622