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carcinoid syndrome - djyoti
#1
tel me more

which vitamin deficiency is related?
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#2
niacin deficiency
increased secrn of serotonin due to carcinoid tumors39% small intestine
26% appendix
15% rectum
10% bronchial system of the lungs
5-7% colon
2-4% stomach
2-3% pancreas
Intermittent migratory Flushing of head and neck skin
Explosive Diarrhea
Nausea and Vomiting
Abdominal pain or cramping
Bronchoconstriction
Cardiovascular Changes
Thickening of endocardium (valves, chambers)
Tricuspid insufficiency
Pulmonary stenosis
Right Heart Failure
Telangiectasia
Intestinal hypermotility (borborygmi
Labs
24 hour Urine 5-hydroxyindoleacetic acid (5-HIAA)
Management
Octreotide 75 to 150 ug up to 750 ug q8 hours
Indications: Flushing
Adverse Effects
Hypoglycemia
Steatorrhea
Cholelithiasis
Alpha-Interferon
Possibly efficacious as adjunctive therapy
Antihistamines
May be useful in histamine-related tumors
Surgery
Excision of primary tumor or tumor debulking
Tumor debulking




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#3
thanks

ok

what is the prognosis?
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#4
tumors that are somewhat larger and have spread to local tissues and local lymph nodes but which, along with these locally invaded tissues, are still totally removable surgically, the average survival has been 8 years with a range up to 23 years.
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