04-30-2006, 07:46 PM
PRIMARY BILIARY CIRRHOSIS
-there is destruction of intrahepatic duct ( micro ducts )
-associated with auto immune diseases such as SLE,SJOGERN ,RA
-common in women
-direct bilirubin,alkaline phosphate & increases
- associated with anti mitrochondrial antibody
-diagnosis liver biopsy
rx.... ursodeoxycholic acid initiallly
liver transplant definitive
PRIMARY SCLEROSING CHOLANGITIS
-intra and extra bile duct both involve
-associated with IBD especially ulcerative colitis
-young men
-direct bilirubin and alkaline phosphate are increase
-associated with A-NCA ( LOSE ASSOCIAYTION )
-INCREASE RISK OF CHOLANGIOCARCINOMA
-diagnosis ercp
-rx liver transplant
-there is destruction of intrahepatic duct ( micro ducts )
-associated with auto immune diseases such as SLE,SJOGERN ,RA
-common in women
-direct bilirubin,alkaline phosphate & increases
- associated with anti mitrochondrial antibody
-diagnosis liver biopsy
rx.... ursodeoxycholic acid initiallly
liver transplant definitive
PRIMARY SCLEROSING CHOLANGITIS
-intra and extra bile duct both involve
-associated with IBD especially ulcerative colitis
-young men
-direct bilirubin and alkaline phosphate are increase
-associated with A-NCA ( LOSE ASSOCIAYTION )
-INCREASE RISK OF CHOLANGIOCARCINOMA
-diagnosis ercp
-rx liver transplant