genetics - hellohie

[ArchivalUser]

17-year-old girl has hemophilia A. Her older brother also has hemophilia A, but neither of their parents is affected. Which of the following is the most likely explanation for the development of hemophilia in this girl?
0 A) Aneuploidy
0 6) Balanced autosomal translocation
0 C) Inheritance of defective factor Vlll alleles from both parents
0 D) Skewed X-chromosome inactivation
0 E) Unequal recombination

[ArchivalUser]

d..

but the questions u posted before this are screwyyyy!!!

[ArchivalUser]

(D)here the X from the father is normal.(because son is affected which means X from mother is diseased and father shud have disease if X is diseased as he as only one X)
so in the daughter the X from father is inactivated.SKEWED here means that its a selective inactivation of father's X. even in stats we means it is inclined towards a particular direction it is not equally chanced. here its the same.