08-06-2006, 08:10 AM
Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the entry step to the hexose monophosphate shunt. Males hemizygous for a mutation in the X-linked gene encoding this enzyme may develop a continuous anemia or a drug-induced anemia, depending upon the site in the protein that is altered by the mutation. Which of the following mutations would result in a continuous anemia in a hemizygous male?
mutations altering the N-terminal region of the enzyme
mutations altering the C-terminal region of the enzyme
mutations affecting the active site of the enzyme
mutations changing amino acids in the coenzyme-binding site of the enzyme
both © and (D) would produce constant anemia
mutations altering the N-terminal region of the enzyme
mutations altering the C-terminal region of the enzyme
mutations affecting the active site of the enzyme
mutations changing amino acids in the coenzyme-binding site of the enzyme
both © and (D) would produce constant anemia