jaundice - saonew

[ArchivalUser]

A patient presents to a physician with jaundice. Physical examination reveals a nodular, enlarged liver. CT of the abdomen shows a cirrhotic liver with a large mass. CT-guided biopsy of the mass demonstrates a malignant tumor derived from hepatic parenchymal cells. Infection with which of the following viruses would most likely be directly related to the development of this tumor?



(A) Epstein-Barr virus (EBV)

(B) Hepatitis B virus (HBV)

© Human herpesvirus type 8 (HHV 8)

(D) Human papillomavirus (HPV)

(E) Human T-lymphocyte virus (HTLV-1)

[ArchivalUser]

b....

[ArchivalUser]

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[ArchivalUser]

(B) Hepatitis B virus (HBV

[ArchivalUser]

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[ArchivalUser]

The correct answer is B. The tumor is hepatocellular carcinoma, which usually develops in the setting of cirrhosis owing to a variety of damaging agents, including hepatitis B virus (HBV) infection, alcohol use, and hemachromatosis.



Epstein-Barr virus (EBV; choice A) is associated with Burkitt lymphoma and nasopharyngeal carcinoma.



Human herpesvirus type 8 (HHV 8; choice C), a member of the herpes family, is associated with Kaposi sarcoma.



Human papillomavirus (HPV; choice D) is associated with cervical, penile, and anal carcinoma.



Human T-lymphocyte virus (HTLV-1; choice E) is associated with adult T-cell leukemia.