01-27-2007, 03:44 PM
A 68-year-old woman has been placed in a nursing home by her son because she can no longer be cared for at home. She has difficulty keeping her room in order. She misplaces articles of clothing and sometimes dresses herself in an odd fashion. These problems have gotten progessively worse over the past 6 years. She has been continually wandering away from the house and getting lost in the neighborhood over the past 6 months. She took early retirement as an accountant because she was having trouble keeping her clients accounts in order. There is no history of trauma. She has no history of seizures. Which set of histopathologic findings is most typical for her underlying disease process?
A Atrophy of caudate nucleus and gliosis
B Wallerian degeneration and gliosis
C Substantia nigra depigmentation and loss of neurons
D Grouped atrophy of muscle with anterior horn cell loss
E Neurofibrillary tangles and senile neuritic plaques
A Atrophy of caudate nucleus and gliosis
B Wallerian degeneration and gliosis
C Substantia nigra depigmentation and loss of neurons
D Grouped atrophy of muscle with anterior horn cell loss
E Neurofibrillary tangles and senile neuritic plaques