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toxic q - math3
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02-07-2007, 06:38 AM
8-36. A 45-year-old male with alcoholic cirrhosis is seen in the ED
because of a laceration of the scalp. Of the following local anesthetics, which would potentially be toxic? a. Lidocaine b. Benzocaine c. Procaine d. Tetracaine
02-07-2007, 07:03 AM
please post explanations for your Q if you have them...thanks
02-07-2007, 09:51 AM
poor liver function (cirrhosis ) are unable to biotransform amide
02-07-2007, 10:06 AM
8-36. The answer is a. (Hardman, p 338. Katzung, pp 438“439.) Ester-type
local anesthetics are mainly hydrolyzed by pseudocholinesterases. Amidetype local anesthetics are hydrolyzed by microsomal enzymes in the liver. Of the listed agents, only lidocaine is an amide and can be influenced by liver dysfunction. |
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