Gleason sccore - writingbook

[ArchivalUser]

Any idea wht does Gleason score mean with regards to Prostate??

Thanks in Advance for explaining

[ArchivalUser]

In prostate cancer ,grading is done by using gleason score which is the sum up of two numbers for example 3+3 or 4+5,these numbers represent the most common pathological features on and the second most common on microscopic examination.Minimum Gleason score is 2(1+1) and maximum is 10(5+5).

the higher the score the poorer the prognosis.usually score above 7 is considerd as high risk

[ArchivalUser]

thank u very much pejman

[ArchivalUser]

thx a lot pejman always knew it was grading for prostate ca but did not know how it was done

[ArchivalUser]

Yes, thx, and I found this, it is good to be impeled to study in this forum....

The Gleason scoring system is based on microscopic tumor patterns assessed by a pathologist while interpreting the biopsy specimen. When Prostate Cancer is present in the biopsy, the Gleason score is based upon the degree of loss of the normal glandular tissue architecture (i.e. shape, size and differentiation of the glands) as originally described and developed by Dr. Donald Gleason in 1974.
The classic Gleason scoring diagram shows five basic tissue patterns that are technically referred to as tumor œgrades. The subjective microscopic determination of this loss of normal glandular structure caused by the cancer is abstractly represented by a grade, a number ranging from 1 to 5, with 5 being the worst grade possible. The Gleason score (GS) and the Gleason sum are one and the same.
The biopsy Gleason score is a sum of the primary grade (representing the majority of tumor) and a secondary grade (assigned to the minority of the tumor), and is a number ranging from 2 to 10. The higher the Gleason score, the more aggressive the tumor is likely to act and the worse the patient™s prognosis.