03-27-2007, 02:36 PM
A 10-year-old boy is referred to the physician because of learning problems and a lack of motivation in school. His family history is unremarkable. Physical examination is normal except for single palmar creases of the hands and curved fifth fingers (clinodactyly). The physician decides to order a karyotype. Which of the following indications for obtaining a karyotype would best explain the physician's decision in this case?
A. A couple with multiple miscarriages, or a person who is at risk for an inherited chromosome rearrangement
B. A child with ambiguous genitalia who needs genetic sex assignment
C. A child with an appearance suggestive of Down's syndrome or other chromosomal disorder
D. A child with mental retardation and/or multiple congenital anomalies
E. A child who is at risk for
A. A couple with multiple miscarriages, or a person who is at risk for an inherited chromosome rearrangement
B. A child with ambiguous genitalia who needs genetic sex assignment
C. A child with an appearance suggestive of Down's syndrome or other chromosomal disorder
D. A child with mental retardation and/or multiple congenital anomalies
E. A child who is at risk for